Deputy President Jacob Zuma, Mbeki's predecessors Nelson Mandela and FW de Klerk, Archbishop Desmond Tutu and several Cabinet ministers are to accompany the president.
Among the other delegation members are Kaizer Chiefs boss Kaizer Motaung, former Ghanaian soccer star Abedi Pele and Oscar winner Charlize Theron.
Mandela and Theron's participation is subject to confirmation, Khoza said at a banquet in Midrand.
SA 2010 Bid Committee chairman Irvin Khoza, Danny Jordaan, the chief executive of the 2010 World Cup Bid, senior SA Football Association officials, Naspers boss Koos Bekker and Professor Michael Katz are also going to Switzerland for the announcement.
Khoza said some members of the South African delegation are expected to fly to Zurich on Wednesday. The rest would follow later.
South Africa is among five African countries competing to win the right to host the 2010 Soccer World Cup, and most commentators have put South Africa or Morocco, the other contender, as the hottest favourites. The other countries were Libya, Tunisia and Egypt.
The Fifa inspection team rated Tunisia and Libya as not ready to host the 2010 Soccer World Cup.
It said South Africa, in its second attempt, was ready to host an excellent World Cup, with Tunisia and Egypt only being ready to host a good tournament.
World football governing body Fifa is expected to announce the host country at its headquarters in Zurich on Saturday.
Correctional Services Minister Ngconde Balfor - until recently sports minister - said earlier that South Africa would take her icons to Zurich to show that the country really wanted to host the prestigious event.
"We will take every person and every icon of South Africa like Mandela and the President of our country (Mbeki).
"We want, really, to get it this time," Balfour told SABC TV news. Balfour is a delegation member.
Zuma said South Africa was confident that it would win the right to host the 2010 Soccer World Cup.
"We are confident of a positive outcome (on Saturday), and with good reason," he said in a speech prepared for delivery at the banquet.
Mandela, Cabinet ministers and soccer administrators attended the gala event.
Zuma said if South Africa won the right to host the tournament, the country would present it to Mandela just to thank him for his work to his people.
"We are sure that the delegation we send today will be fully armed with the Madiba magic, whose wonders we have all seen."
He said South Africa was not resting on her laurels after losing to Germany the right to host the tournament in 2006.
"We took the challenge of losing the 2006 Bid in our stride, went straight back to work, and delivered one of the biggest bid campaigns to convince the world that we are ready to host the 2010 tournament," said Zuma.
"The sterling work so far done by the 2010 World Cup Bid Committee was only recently confirmed by a Fifa Technical Committee Report that pitched South Africa above the rest of the contenders from our continent." - Sapa
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