Footnotes

1 Abbott Laboratories, Diagnostic Division, 68-0158/R12; December 1996

2 HIV-1 Western Blot Kit, Epitope, Inc., Organon Teknika Corporation PN201-3039 Revision #8

3 Roche Diagnostic Systems, Inc., Amplicor HIV-1 Monitor Test Kit. US:83088. June 1996)(13-06-83088-001

4 World Health Organisation. 1986. Acquired immunodeficiency sydrome. WHO/CDC case definition for AIDS. Weekly Epidemiological Records. 61:69-76.

Bangui definition: 2 major signs plus one minor sign: in an adult in the absence of exclusion criteria or in a patient with generalised Kaposi's Sarcoma or in a patient with cryptococcal meningitis.

Major signs: (1) weight loss of at least 10% of body weight; (2) diarrhoea for at least one month; (3) fever for at least one month (intermittent or constant).

Minor signs: (1) oropharyngeal candidiasis; (2) pruritic skin rash; (3) herpes zoster; (4) generalised lymphadenopathy; (5) cough for at least one month (without TB); (6) chronic ulcerated herpes simplex; (7) tuberculosis

Exclusion criteria: cancer, severe malnutrition or other recognised causes

5 Padian NS, Shiboski SC, Glass SO, Vittinghoff E. 1997. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study. Am. J. Epidemiol. 146:350-357.

6 ccr5 gene is known to be protective against HIV infection in the sense that it reduces risk of transmission and infection. If infection has taken place, it reduces the risk of progression of AIDS.

7 MMWR Vol 36(31): 509 – 515, 1987

MMWR Vol 38: S-7, 1989

8 Weekly Epidemiological Record Vol 72: 81 – 88, 1997

9 Jay Levy. 1996. JAMA. 276:161-162

Jay Levy. 1998. Lancet.l 352: 982-983

10 Phillips and Smith. 1997. NEJM. 13: 958-959

11 Abrams.1996. Synapse. 4: 1-5

12 Escobar-Gutierrez et al. 1996. International Journal of Leprocy, 64:417-427